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1

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

Visnes, Torkild, Cázares-Körner, Armando, Hao, Wenjing, Wallner, Olov, Masuyer, Geoffrey, Loseva, Olga, Mortusewicz, Oliver, Wiita, Elisée, Sarno, Antonio, Manoilov, Aleksandr, Astorga-Wells, Juan, Je

Journal:

Year:

2018

Language:

english

File:

PDF, 968 KB

english, 2018

2

Spatiotemporal dynamics of regulatory protein recruitment at DNA damage sites

Oliver Mortusewicz, Heinrich Leonhardt, M. Cristina Cardoso

Journal:

Journal of Cellular Biochemistry

Year:

2008

Language:

english

File:

PDF, 263 KB

english, 2008

3

XRCC1 and PCNA are loading platforms with distinct kinetic properties and different capacities to respond to multiple DNA lesions

Oliver Mortusewicz, Heinrich Leonhardt

Journal:

BMC Molecular Biology

Year:

2007

Language:

english

File:

PDF, 725 KB

english, 2007

4

CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair

Cecilia E. Ström, Oliver Mortusewicz, David Finch, Jason L. Parsons, Anne Lagerqvist, Fredrik Johansson, Niklas Schultz, Klaus Erixon, Grigory L. Dianov, Thomas Helleday

Journal:

Year:

2011

Language:

english

File:

PDF, 1.02 MB

english, 2011

5

Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress

Jones, R M, Mortusewicz, O, Afzal, I, Lorvellec, M, García, P, Helleday, T, Petermann, E

Journal:

Year:

2013

Language:

english

File:

PDF, 2.97 MB

english, 2013

6

240 The combination of Chk-1 and ATR inhibitor synergistically kills cancer cells

Sanjiv, K., Hagenkort, A., Reaper, P.M., Koolmeister, T., Mortusewicz, O., Schultz, N., Scobie, M., Berglund, U.W., Charlton, P.A., Pollard, J.R., Helleday, T.

Journal:

European Journal of Cancer

Year:

2014

Language:

english

File:

PDF, 62 KB

english, 2014

7

MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos

Ruzov, A., Shorning, B., Mortusewicz, O., Dunican, D. S., Leonhardt, H., Meehan, R. R.

Journal:

Development (The Company of Biologists)

Year:

2009

Language:

english

File:

PDF, 2.57 MB

english, 2009

8

Recruitment of DNA methyltransferase I to DNA repair sites

Mortusewicz, O., Schermelleh, L., Walter, J., Cardoso, M. C., Leonhardt, H.

Journal:

Proceedings of the National Academy of Sciences

Year:

2005

Language:

english

File:

PDF, 524 KB

english, 2005

9

PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms

Mortusewicz, O., Fouquerel, E., Ame, J.-C., Leonhardt, H., Schreiber, V.

Journal:

Nucleic Acids Research

Year:

2011

Language:

english

File:

PDF, 9.97 MB

english, 2011

10

Role for hACF1 in the G2/M damage checkpoint

Sanchez-Molina, S., Mortusewicz, O., Bieber, B., Auer, S., Eckey, M., Leonhardt, H., Friedl, A. A., Becker, P. B.

Journal:

Nucleic Acids Research

Year:

2011

Language:

english

File:

PDF, 4.72 MB

english, 2011

11

Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression

Boehler, C., Gauthier, L. R., Mortusewicz, O., Biard, D. S., Saliou, J.-M., Bresson, A., Sanglier-Cianferani, S., Smith, S., Schreiber, V., Boussin, F., Dantzer, F.

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 851 KB

english, 2011

12

A Fluorescent Two-hybrid Assay for Direct Visualization of Protein Interactions in Living Cells

Zolghadr, K., Mortusewicz, O., Rothbauer, U., Kleinhans, R., Goehler, H., Wanker, E. E., Cardoso, M. C., Leonhardt, H.

Journal:

Molecular & Cellular Proteomics

Year:

2008

Language:

english

File:

PDF, 837 KB

english, 2008

13

PC4 promotes genome stability and DNA repair through binding of ssDNA at DNA damage sites

Mortusewicz, O, Evers, B, Helleday, T

Journal:

Year:

2015

Language:

english

File:

PDF, 2.66 MB

english, 2015

14

Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells

Mortusewicz, O., Ame, J.-C., Schreiber, V., Leonhardt, H.

Journal:

Nucleic Acids Research

Year:

2007

Language:

english

File:

PDF, 20.69 MB

english, 2007

15

Recruitment of RNA polymerase II cofactor PC4 to DNA damage sites

Mortusewicz, O., Roth, W., Li, N., Cardoso, M. C., Meisterernst, M., Leonhardt, H.

Journal:

The Journal of Cell Biology

Year:

2008

Language:

english

File:

PDF, 2.07 MB

english, 2008

16

Early replication fragile sites: where replication–transcription collisions cause genetic instability

Mortusewicz, Oliver, Herr, Patrick, Helleday, Thomas

Journal:

The EMBO Journal

Year:

2013

Language:

english

File:

PDF, 241 KB

english, 2013

17

Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair

S. Xie, O. Mortusewicz, H. Ma, P. Herr, R. Poon, T. Helleday, C. Qian

Year:

2015

Language:

english

File:

PDF, 5.17 MB

english, 2015

18

DNA-PKcs and PARP1 bind to unresected stalled DNA replication forks where they recruit XRCC1 to mediate repair

Ying, S., Chen, Z., Medhurst, A. L., Neal, J. A., Bao, Z., Mortusewicz, O., McGouran, J., Song, X., Shen, H., Hamdy, F. C., Kessler, B. M., Meek, K., Helleday, T.

Journal:

Cancer Research

Year:

2015

Language:

english

File:

PDF, 3.07 MB

english, 2015

19

Differential recruitment of DNA Ligase I and III to DNA repair sites

Mortusewicz, O.

Journal:

Nucleic Acids Research

Year:

2006

Language:

english

File:

PDF, 6.82 MB

english, 2006

20

Generation of an alpaca-derived nanobody recognizing γ-H2AX

Rajan, Malini, Mortusewicz, Oliver, Rothbauer, Ulrich, Hastert, Florian D., Schmidthals, Katrin, Rapp, Alexander, Leonhardt, Heinrich, Cardoso, M. Cristina

Journal:

Year:

2015

Language:

english

File:

PDF, 2.20 MB

english, 2015

21

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

Sanjiv, Kumar, Hagenkort, Anna, Calderón-Montaño, José Manuel, Koolmeister, Tobias, Reaper, Philip M., Mortusewicz, Oliver, Jacques, Sylvain A., Kuiper, Raoul V., Schultz, Niklas, Scobie, Martin, Char

Journal:

Year:

2016

Language:

english

File:

PDF, 4.70 MB

english, 2016

22

Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression

Christian Boehler, Laurent R. Gauthier, Oliver Mortusewicz, Denis S. Biard, Jean-Michel Saliou, Anne Bresson, Sarah Sanglier-Cianferani, Susan Smith, Valérie Schreiber, François Boussin, Francoise Dan

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 1.40 MB

english, 2011

23

Recruitment of RNA Polymerase II Cofactor PC4 to DNA Damage Sites

Oliver Mortusewicz, Wera Roth, Na Li, M. Cristina Cardoso, Michael Meisterernst and Heinrich Leonhardt

Journal:

The Journal of Cell Biology

Year:

2008

Language:

english

File:

PDF, 1.34 MB

english, 2008

24

Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair

Xie, Si, Mortusewicz, Oliver, Ma, Hoi Tang, Herr, Patrick, Poon, Randy Y.C., Helleday, Thomas, Qian, Chengmin

Journal:

Year:

2016

File:

PDF, 94 KB

2016

25

A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair

Herr, Patrick, Lundin, Cecilia, Evers, Bastiaan, Ebner, Daniel, Bauerschmidt, Christina, Kingham, Guy, Palmai-Pallag, Timea, Mortusewicz, Oliver, Frings, Oliver, Sonnhammer, Erik, Helleday, Thomas

Journal:

Year:

2015

Language:

english

File:

PDF, 4.18 MB

english, 2015

26

Genome-wide screen of cell-cycle regulators in normal and tumor cells identifies a differential response to nucleosome depletion

Sokolova, Maria, Turunen, Mikko, Mortusewicz, Oliver, Kivioja, Teemu, Herr, Patrick, Vähärautio, Anna, Björklund, Mikael, Taipale, Minna, Helleday, Thomas, Taipale, Jussi

Journal:

Year:

2017

Language:

english

File:

PDF, 822 KB

english, 2017

27

The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing

Tanikawa, M, Sanjiv, K, Helleday, T, Herr, P, Mortusewicz, O

Journal:

Year:

2016

Language:

english

File:

PDF, 3.71 MB

english, 2016

28

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

Sanjiv, Kumar, Hagenkort, Anna, Calderón-Montaño, José Manuel, Koolmeister, Tobias, Reaper, Philip M., Mortusewicz, Oliver, Jacques, Sylvain A., Kuiper, Raoul V., Schultz, Niklas, Scobie, Martin, Char

Journal:

Year:

2016

Language:

english

File:

PDF, 5.66 MB

english, 2016

29

Restriction of AID activity and somatic hypermutation by PARP-1

Tepper, Sandra, Mortusewicz, Oliver, Członka, Ewelina, Bello, Amanda, Schmidt, Angelika, Jeschke, Julia, Fischbach, Arthur, Pfeil, Ines, Petersen-Mahrt, Svend K, Mangerich, Aswin, Helleday, Thomas, Le

Journal:

Nucleic Acids Research

Year:

2019

Language:

english

File:

PDF, 4.26 MB

english, 2019

30

Processive DNA synthesis is associated with localized decompaction of constitutive heterochromatin at the sites of DNA replication and repair

Chagin, Vadim O., Reinhart, Britta, Becker, Annette, Mortusewicz, Oliver, Jost, K. Laurence, Rapp, Alexander, Leonhardt, Heinrich, Cardoso, M. Cristina

Journal:

Nucleus (Landes Bioscience)

Year:

2019

Language:

english

File:

PDF, 6.09 MB

english, 2019

31

THE RNA HELICASE DDX17 PROTECTS ACUTE MYELOID LEUKEMIA CELLS AGAINST DNA DAMAGE

Jagdhane, P., Garg, S., Xia, J., He, L., Misiak, D., Mortusewicz, O., Helleday, T., Müller-Tidow, C., Koehn, M., Pabst, C.

Journal:

Year:

2019

File:

PDF, 303 KB

2019

32

MTH1 inhibitor TH588 disturbs mitotic progression and induces mitosis-dependent accumulation of genomic 8-oxodG

Rudd, Sean G, Gad, Helge, Sanjiv, Kumar, Amaral, Nuno, Hagenkort, Anna, Groth, Petra, StrÃ¶m, Cecilia E., Mortusewicz, Oliver, Warpman Berglund, Ulrika, Helleday, Thomas

Journal:

Cancer Research

Year:

2020

File:

PDF, 5.31 MB

2020

33

OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions

Hanna, Bishoy M. F., Helleday, Thomas, Mortusewicz, Oliver

Journal:

Year:

2020

File:

PDF, 3.60 MB

2020

34

Targeting OGG1 arrests cancer cell proliferation by inducing replication stress

Visnes, Torkild, BenÃtez-Buelga, Carlos, CÃ¡zares-KÃ¶rner, Armando, Sanjiv, Kumar, Hanna, Bishoy M F, Mortusewicz, Oliver, Rajagopal, Varshni, Albers, Julian J, Hagey, Daniel W, Bekkhus, Tove, Eshtad

Journal:

Nucleic Acids Research

Year:

2020

File:

PDF, 3.98 MB

2020

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